Essentials in clinical application of p53 for tumors intervention-example of liver cancer / 介入放射学杂志

ABSTRACT

Recombinant human adenovirus p53(Ad-p53)injection has been used for treating tumors in combination with several local therapeutic methods. Taking liver cancer as an example,this article introduces the combination of Ad-p53 in procedures of interventional therapy. Mechanisms of their effects are emphasized to pursue an optimal synergism in killing tumors. Intratumoral injection is suggested as the first choice of Ad-p53 administration with the least recommended dosage for a single tumor. The optimal time for intervention of liver cancer is supposed to be 2 to 5 days after the administration of Ad-p53. There are several theories on the therapeutic method taking p53 as a target,some of them are contradictional; therefore one has to select either activating or inhibiting the p53 pathway beforehand. For advanced malignancies,the selection should be cautious for appropriater cases from the proper candidates.