The establishment of the animal model of acute superior mesenteric artery embolization / 介入放射学杂志

ABSTRACT

Objective To establish an animal model of acute superior mesenteric artery embolization suitable for follow-up embolectomy study. Methods Via the femoral artery approach selective catheterization of the main branch of superior mesenteric artery with a 8 F-guiding catheter was performed in 8 hybrid dogs,which was followed by the injection of auto-clots prepared in vitro until the main branch of superior mesenteric artery was completely occluded,which was confirmed with angiography. Follow-up angiography of superior mesenteric artery was carried out 2,4,6 and 8 hours after the procedure to check the stability of the auto-clots and the embolization. Intraperitoneal explore through abdominal incision was performed and abnormal bowel was taken out for pathologic examination. Results The acute superior mesenteric artery embolization model was successfully established in all 8 dogs. Intestinal ischemia was found in all of the 8 dogs. Macropathologically and microscopically,the intestinal ischemic damage deteriorated gradually with time. Conclusion Interventional technique can successfully establish appropriate animal model of acute superior mesenteric artery embolization,which is suitable for the follow-up embolectomy study.