Expression of EGFR ,WT-1,CD10 and OTR in endometrial stromal sarcomas / 重庆医科大学学报

ABSTRACT

Objective:To explore the expression of Epidermal growth factor recepto(rEGFR),WT-1,CD10 and Oxytocin receptors(OTR)in endometrial stromal sarcomas,and their applications in the diagnosis and differential diagnosis of Endometrial stromal sarcoma(ESS). Methods: Using the routine SP immunohistochemical technique ,the expression of epidermal growth factor receptor(EFGR),the Wilms' tumor gene(WT-1),CD10 and oxytocin receptors(OTR)was studied in 40 cases of endometrial stromal sarcoma (ESS),including 35 low-grade cases and 5 cases of undifferentiated endometrial sarcoma(UES),15 cases of highly cellular leiomyoma(HCL)and 10 cases of leiomyosarcoma(LMS). Results: Immunoreactives of ESS for EGFR,WT-1,CD10 and OTR were 67.5%(27/40),52.5%(21/40),82.5% (33/40)and 7.25%(3/40)respectively;whereas in the first control group,the positive rates of HCL were 80.0%(12/15),46.7%(7/15), 13.3%(2/15)and 100%(15/15);and,in the second control one,the positive rates of LMS were 70.0%(7/10),50.0%(5/10),0(0/10)and 100%(10/10),respectively (P