A toxicological study of Fuyuan capsule / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-579922
ABSTRACT
Objective:
To observe the acute toxicity and the long-period toxicity reaction of Fuyuan Capsule(FYC) to provide the reference dosage for human beings.Methods:
Tests of acute oral toxicity 40 mice (Kun Ming kind) were randomly divided into two groups,the drug test group and the control group. The maximum administration dosage(MAD) of FYC were determined by iq administration in mice. Tests of long oral toxicity80 SD rats were randomly divided into four groupshigh,middle,and low dose of FYC group and control group.FYC was continuously administered for 90 days.Rats were given drugs every day. When the experiment was finished and withdrawed for 14 days,rats were killed and the growth condition,blood cell counting and biochemical targets were measured.Histomorphologieal examination were simultaneously performed.Results:
The MAD of FYC by iq administration was greater than 30g/kg in mice.In the long-period toxicity test,after administered repeatedly for 90 days,in high dose group AST,ALT and Crea increased(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Chongqing Medical University
Année:
2007
Type:
Article
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