Effects of Matrine, Oxymatrine and Sophordine on Activity and TNF-? Secretion of Macrophage RAW264.7 / 中国中医药信息杂志

ABSTRACT

Objective To observe the effects of matrine, oxymatrine and sophordine on activity and TNF-? secretion of macrophage RAW264.7. Methods Macrophage were cultivated in 6 holes board and cultivated 1 day with different concentration matrine, oxymatrine and sophordine. Macrophage activity was measured with MTT and content of TNF-? in collected culture medium was measured with ELISA. Results Macrophage activity and the function of secreting TNF-? was restrained by matrine, oxymatrine and sophordine. The higher concentration of matrine, oxymatrine and sophordine was, the more intense the inhibiting effect was. The effect of matrine was more intense to the function of secreting TNF-? of macrophage. Conclusion Matrine, oxymatrine and sophordine can restrain macrophage activity and the function of secreting TNF-?, the effect of matrine is the most intense.