Liposomal prostaglandin E1 can reduce inflammatory factors and the incidence of adverse cardiac events for percutaneous coronary intervention / 重庆医科大学学报

ABSTRACT

Objective:To observe the inflammatory factors for early use of lipid carriers prostaglandin E1 on percutaneous coronary intervention(PCI).Method:74 patients treated with PCI were randomly divided into experimental and control groups.PGE1 20?g + 40 ml normal saline intravenously,Bid ? 3 d,were used in experimental groups,but not to the patients in the control group.The basis treatment was the same.CRP,IL-6,TNF-? were checked in the pre-operative 1 d,after 2 d,after 5 d,after 4 w,and after 60 d,the early incidence of cardiac events were observed.Results:CRP levels in every patients for two groups increased at 1 d(P0.05).After 5 d～4 w,CRP level in the experimental group were declined than 1 d(P 0.05).Inflammatory factor IL-6,TNF-? and CRP showed the same trend.Conclusions:CRP,IL-6 and TNF-? may have increased in the early stage of post-PCI,and the use of Lipo-PGE1 may be effective in containing the level of inflammatory factors.