Mechanism and protective effects of Shenhuang Jingkang Tablet on cervical spondylosis / 中成药

ABSTRACT

AIM: To assess the therapeutic effects and mechanisms of Shenhuang Jinkang Tablet(Radix et rhi-zoma salviae miltiorrhizae,Radix astragali,Rhizoma atractylodis macrocephalae,Rhizoma curcumae longae,Radix angelicae sinensis,Concha ostreae,Concha ostreae praeparatum) on cervical spondylosis in the rat model.METH-ODS Sprague-Dawley rats were divided into 6 groups at random.The cervical spondylosis rat model was induced,and then administered with normal saline,Shenhuang Jingkang Tablet(500 mg/kg,1 000 mg/kg,2 000 mg/kg) and Jingfukang,respectively.To observe the movement,sensation and morphological change in rat model.The contents of SOD,MDA,IL-6 in serum were tested.RESULTS: As compared with the control group,the activity of cervical part was significantly improved,the oppression was relieved.The average functional angle increased in Shenhuang Jingkang Tablet groups.Difference was significant(P