Effects of selective psychological intervention on cytokine and unhealthy emotion in patients with breast cancer / 重庆医科大学学报

ABSTRACT

Objective:To study the role of selective psychological intervention on peripheral blood cytokine(interleukin-2,interleukin-4,tumor necrosis factor-?)(IL-2,IL-4,TNF-?)and unhealthy emotion in patients with chemotherapeutical breast cance.Methods:Randomized-control study method was adopted.Eighty chemotherapeutical inpatients with breast cancer were divided into intervention group and control group(40 patients in each group).Patients in both groups received mutine chemotherapy and health education,while the intervention group also received selective psychological intervention.The psychological and behavior rating were observated with Zung anxiety scale(SAS)/Zung depression scale(SDS)and symptom checklist(SCL-90)pre-and three month post-chemotherapy.Psychological intervention methods were selected independently and completed by patients.The effect of selective psychological intervention on unhealthy emotions were observed in breast cancer inpatients undergoing chemotherapeutics.The changes of IL-2/IL-4/TNF-?in peripheral blood were detemined by radioimmunity.Results:The breast cancer inpatients in both groups were noticeably depressed after chemotherapy(P0.05).Conclusion:The selective psychological intervention could inhibit the unhealthy emotion of breast cancer patients undergoing chemotherapy and increase the content of some cytokines in peripheral blood,which may be related with immunity enhancement.