Study of G-6-PD Deficiency of Blood Donors in Suining Region, Sichuan Province and Influence of Being Transfused with Blood from Donors Eating Broad Beans on Children with Favism / 中国输血杂志

ABSTRACT

A study of G-6-PD state in red cells of 2483 blood donors was performed using the improved blue tetrazolium method ,indicating that 8.3% of the donors studied were in G-6-PD deficiency and 2. 1% of the donors studied were in severe G-6-PD deficiency. The files of blood donor G-6-PD state were established to prevent the children with favism from being transfused with G-6-PD deficient blood, thereby the safety of blood transfusion could be enhanced. The impact of being transfused with the blood extracted from the donors at different time (2~4 hr. 12-24hr. and 2-3 days )after eating broad beans on the children with favism was observed. There was no obvious difference in the improvement of clinical symptoms,restoration of hemoglobin in peripheral blood and change of G-6-PD activity between the tested and control groups. There were no found the cases of rehemolytic reaction in either group,indicating that being transfused with the blood from donors eating the broad beans had no evident adverse influence on the children with favism during the "refractory period" following the acute hemolysis.