Comparison of Hemostatic Effects between a Combination Therapy Including Endoscopic Injection Therapy and Omeprazole and a Single Intravenous Omeprazole Therapy in Patients with Bleeding Peptic Ulcers / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
;
: 221-228, 2005.
Article
Dans Coréen
| WPRIM
| ID: wpr-58239
ABSTRACT
BACKGROUND/AIMS:
This study was performed to test whether there is some difference between combined endoscopic therapy with PPI infusion and intravenous PPI therapy alone.METHODS:
A total of seventy-three high-risk patients with ulcer bleeding and non-bleeding visible vessels or fresh adherent clots resistant to irrigation were randomized to medical therapy [intravenous omeprazole therapy alone 40 mg IV per day for 3~5 days] or to endoscopic combination therapy [endoscopic epinephrine (1 10,000 in normal saline) or ethanol injection followed by intravenous omeprazole infusion].RESULTS:
Patients were similar at study entry. Ulcer bleeding recurred in two patients who received combined endoscopic therapy (2/35, 5.7%) while ulcer bleeding recurred in ten patients who received intravenous omeprazole alone (10/38, 26.3%) (p < 0.05). Two patients (2/35, 5.7%) in the combined therapy group and five patients (5/38, 13.2%) in the omeprazole infusion alone group had surgery for intractable bleeding (p=0.281). One patient in each group died within the hospital stays (p=0.953).CONCLUSIONS:
The combination of endoscopic injection therapy with omeprazole infusion is superior to omeprazole infusion alone for preventing recurrent bleeding from ulcers with nonbleeding visible vessels or adherent clots.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ulcère peptique
/
Ulcère
/
Oméprazole
/
Épinéphrine
/
Éthanol
/
Hémorragie
/
Durée du séjour
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Gastrointestinal Endoscopy
Année:
2005
Type:
Article
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