Determination of netilmicin sulfate in serum by high performance liquid chromatography-indirect photometric determination method / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 235-1998.
Article
Dans Chinois
| WPRIM
| ID: wpr-583570
ABSTRACT
OBJECTIVE:
To determine the content of netilmicin sulfate in serum by a high performance liquid chromatography-indirect photometric determination (HPLC-IPD) method.METHOD:
The chromatographic system consisted of Soheisorb C18 column and mobile phase of a solution of methyl alcohol-a buffer of phosphoric acid (pH=2.0) (20∶80), that contained 0.5 mmolL-1 of nicotinamide and 0.3 mmolL-1 of sodium seventhalkyl-sulphonate. The detected wave length was 268 nm. The serum simple of 4 patients was determined.RESULTS:
The mean recovery of was 93.41% and detection limits was 50 μgL-1.CONCLUSION:
The method is constant, sensitive, and has a good concentration. It is good for determination of netilmicin sulfate concentration in serum.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
1998
Type:
Article
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