Granulysin / 医学研究生学报

ABSTRACT

Granulysin is a cytotoxic granule protein,colocalizes with perforin and granzymes in the cytolytic granules of human CTL and NK cells. The released granulysin was found in the sera of healthy individuals and patients. Granulysin exhibits potent cytotoxic activity against tumors and a broad panel of microbes, including bacteria, fungi, and parasites. The serum levels of granulysin is well associated with diverse activities of NK cells and CTL in physiological and pathological settings and could be a useful novel serum marker for acute rejection of grafts and the overall status of host cellular immunity.