Metabolic nuclear receptors and metabolic syndrome / 基础医学与临床

ABSTRACT

Metabolic nuclear receptors consist of a group of nuclear hormone receptor transcription factors including peroxisome proliferator-activated receptors(PPARs),liver X-activated receptors(LXRs) and farnesoid X-activated receptors(FXRs).They have been identified and drawn enormous attention due to key roles in regulating adipogenesis,lipid metabolism,energy metabolism,insulin sensitivity,inflammation,blood pressure,cell growth and differentiation.Growing evidences support a causative relationship between these three metabolic nuclear receptors and the metabolic syndrome,which is characterized by insulin resistance,glucose intolerance or type II diabetes,obesity,dyslipidemia,hypertension,and microalbuminuria.These receptors have also been implicated in pathogenesis of atherosclerosis.Here we review the literature pertaining to the action and physiological role of metabolic nuclear receptors with particular emphasis on their pathogenic roles in the metabolic syndrome.