Effects of hepatitis C virus persistent infection on biological behavior of human placental syncytiotrophoblast in vitro / 医学研究生学报

ABSTRACT

Objective: To investigate the effect of HCV persistent infection on biological behavior of human placental syncytiotrophoblast in vitro. Methods: Using Matrigel invasion assay,cell adhesive assay and migration assay to measure the effect of HCV persistent infection on invasive and relative adhesive and migration ability of human placental syncytiotrophoblast in vitro.Content of HCG in supernatant of the cultured medium was detected to evaluate the change of hormone synthesis and secretion of the infected syncytiotrophoblast.Results: Ability of invasion,adhesion,migration and function of hormone synthesis and secretion of infected syncytiotrophoblast decreased significantly in comparison with cells of control group(P