Relationskip between plasma lysophosphatidic acid concentration and the progression of aortic atherosclerotic lesions in diet induced hyperlipidemic infantile rabbits / 中国介入心脏病学杂志

ABSTRACT

Objective To investigate the relationship between plasma lysophosphatidic acid(LPA) concentration and progression of aortic atherosclerotic lesions for hyperlipidemic diet fed infantile rabbits.Methods Two-month-old infantile rabbits(0.9-1.1 kg) were randomly assigned to normal diet group(group A,n=6) and hyperlipidemic diet group(group B,n=11).Blood lipid levels,LPA,nitric oxide(NO),malondialdehyde(MDA) and superoxide dismutase(SOD) concentrations were taken regularly.The thoracic aorta was taken from a hypertipidemic diet rabbit for pathological study at certion interval of time.Results Electronic microscope analysis revealed subtle changes of aortic wall during 1-2 weeks of the experiment.Fatty streaks(FS) appeared after 4 weeks of hyperlipidemic diet.The degree of FS increased gradually thereafter.Blood lipid levels increased significantly after 1 week of hyperlipidemic diet.Plasma LPA concentration reached its peak level before the appearance of FS.The NO,MDA and SOD concentrations of group B changed significantly proportional to the development of FS.Conclusion Measuring plasma LPA concentration,combined with serum NO,MDA and SOD concentrations can accurately reflect the formation and progression of FS.