Expression of Glycolysis-Related Proteins in Solid Papillary Carcinoma of the Breast According to Basement Membrane Status
Yonsei Medical Journal
;
: 576-583, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-58602
ABSTRACT
PURPOSE:
The aim of this study was to investigate the differences of expression in glycolysis-related proteins such as Glut-1, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4 according to the myoepithelial cell (MEC) and basement membrane (BM) status in solid papillary carcinoma (SPC) of the breast. MATERIALS ANDMETHODS:
Immunohistochemical evaluation of Glut-1, CAIX, and MCT4, as well as p63 and type IV collagen, were performed on 23 SPC cases.RESULTS:
Six and nine cases of SPC showed the presence and absence of myoepithelial cells, respectively, and eight cases belonged to the borderline status (p63-positive MEC on some areas of the outer tumor surface but not in others). BM was partially or completely absent in 14 cases and present in nine cases. SPC lacking BM more frequently showed high expression of CAIX than SPC with BM (p=0.037).CONCLUSION:
In SPC of the breast, a strong expression of CAIX seems to be associated with an increasing degree of loss of BM, which can be interpreted as BM degradation due to the induction of extracellular acidity with increasing expression of CAIX.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Membrane basale
/
Tumeurs du sein
/
Immunohistochimie
/
Carcinome papillaire
/
Marqueurs biologiques tumoraux
/
Transporteur-2 d'acides aminés excitateurs
/
Transporteurs d'acides monocarboxyliques
/
Glycolyse
/
Protéines du muscle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2014
Type:
Article
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