Pathological changes on SARS-CoV infected Microtus brandtii, Lewis rat and Rhesus macaque / 基础医学与临床

ABSTRACT

Objective The pathological changes on SARS CoV infected Microtus brandtii,Lewis rat and Rhesus macaque and the possibility as SARS animal model were studied.Methods The amimals were infected with SARS-CoV through nasal cavity and sacrificed for collecting pathologic tissues after inoculation.The pathological changes,immuno-response and the replication of SARS-CoV in vivo were tested with microscopy,ELISA and virus isolation.Results Similar pathological changes were observed in SARS CoV infected Rhesus macaques,Lewis rats and Microtus brandtii and the pathological changes were similar with those of human.Conclusion All of the tree species of animals infected with SARS-CoV showned similar pathological changes with human SARS case.Among them,SARS-CoV infected Rhesus macaques is the best one in terms of pathological changes.Therefor the infected Rhesus macaque may be one of the most ideal animal model to study the pathogenesis and evaluation of anti-SARS-CoV vaccine.