Fas-FasL and TNF-? Mediated Apoptosis and IL-8 Associated with Pathogenesis of Aged Chronic Obstructive Pulmonary Disease / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the significance of the Fas and TNF-? receptor mediated apoptosis and IL-8 associated with the pathogenesis of aged COPD.METHODS We measured the circulating soluble Fas,tumor(necrosis) factor alpha(TNF-?) and interleukin-8 level in peripheral blood of 40 patients with aged chronic(obstructive) pulmonary disease (COPD).In contrast with the aged COPD group,30 healthy old people were(observed) as a control.RESULTS The level of soluble Fas,TNF-? and IL-8 in peripheral blood of these patients was higher than control((P