The effect of acute hypervolemic hemodilution on the accuracy of target-controlled infusion propofol / 医学研究生学报

ABSTRACT

Objective:To evaluate the effect of acute hypervolemic hemodilution on the accuracy of target-controlled infusion of propofol.Methods:Sixteen ASAⅠ~Ⅱpatients were randomly divided into(acute) hypervolemic hemodilution group(AHHD group,n=8) and control group(control group,n=8).Propofol was infused with target-controlled(Diprifusor-TCI) system.Arterial blood sample was taken for determination of plasma concentration measured by HPLC(Angilent 10 000).Predicted error(PE),median predicted error(MDPE) and median absolute prediction error(MADPE) were calculated.Results:There was remarkable initial overshoot in both groups.PE and absolute PE were(-5.46%) and(13.02%) in AHHD group and-29.32% and 40.84% in control group.The median value of MDPE and MDAPE were(-1.78%) and 19.40% in AHHD group and 28.66% and 42.37% in control group.Conclusion:TCI system with Marsh pharmacokinetic parameters had large difference in measured-predicted concentration.But the accuracy of the TCI system increased with AHHD.