Studies on chemical constituents of the sea cucumber Holothuria fuscocinerea / 中国海洋药物
Chinese Journal of Marine Drugs
;
(6)2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-588050
ABSTRACT
Objective To study the chemical constituents of the sea cucumber Holothuria fuscocinerea collected from the South China Sea.Methods The compounds were isolated by Pyricularia oryzae bioassay-guided fractionation method in combination with extraction and partition as well as multi-chromatography.Their structures were determined on the basis of spectral analysis and chemical evidence.Results Three triterpene glycosides were isolated from the n-BuOH extract and identified as pervicoside C(Ⅰ),holothurin A(Ⅱ) and DS-holoturin B(Ⅲ);Four compounds [uracil(Ⅳ),thymine(Ⅴ),thymidine(Ⅵ) and 2'-deoxyuridine(Ⅶ)] were obtained from the CHCl_(3) extract.Conclusion All the compounds were isolated from this sea cucumber for the first time while Compound Ⅰ was first obtained as pure compound.Compound Ⅰ and Ⅱ were active compounds causing morphological abnormality of P.oryzae mycelia and exhibited cytotoxicity against two cancer cell lines.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Marine Drugs
Année:
2000
Type:
Article
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