Expression of epidermal growth factor receptor,vascular endothelial growth factor and Ki-67 in aged people with non-small cell lung cancer / 医学研究生学报

ABSTRACT

Objective:Studies suggested that some growth factors and their receptors play important roles in the treatment and prognosis of lung cancer.In this study we investigated the expression of epidermal growth factor receptor(EGFR),vascular endothelial growth factor(VEGF),and Ki-67 simultaneously in the tissues of aged patients with non-small cell lung cancer(NSCLC). Methods:The expression levels of EGFR,VEGF,and Ki-67 in 64 cases of aged patients with NSCLC were detected by immunohistochemistry staining.Results:The positive expression of EGFR,VEGF and Ki-67 in the tissue of lung cancer was 59.4%,57.8% and 92.2%,respectively.It is different significantly while compared with control group of benign tissues.The expression levels of EGFR and VEGF are correlated significantly with the pathologic type,differential degree,TNM stage and lymphatic metastasis.The expression level of Ki-67 is related to differential degree and TNM stage of lung cancer.Conclusion:The method of immunohistochemistry to detect multiple biological markers simultaneously is simple and feasible.It can supply important information for the staging and prognoses of patients with NSCLC,and more than that,it can also provide the theoretic basis for the individualized molecular targeting therapy of NSCLC.