Phosphorylation of Extracellular Signal-regulated kinase1/2(ERK1/2) and ets-like Gene-1 in Arterioles in the Patients with Hypertension / 中华高血压杂志

ABSTRACT

Objective To study the roles of extracellular signal-regulated kinase(ERK1/2) and its substrate ets-like gene 1(Elk-1) in essential hypertension.Methods A comparative investigation was carried out to observe the expression of extracellular signal-regulated kinase1/2(ERKl/2) and Elk-1 in vascular smooth muscle cell (VSMC)and endothelium of gastrointestinal arterioles by means of immunohistochemistry in hypertension and nonhypertension patients.Results In the hypertension patients group,the positive rate of phosphorylated-ERK 1/2 in vascular smooth muscle cell(VSMC) and endothelium in gastrointestinal small arteries(8.32%and 4.97%,respectively) was significantly higher than that in the non-hypertension patients group(P