Effect of panaxadiols on AQP1 expression in lungs of hemorrhage-LPS two-hits rats / 吉林大学学报(医学版)
Article
de Zh
| WPRIM
| ID: wpr-591788
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the alteration of aquaporin 1(AQP1) expression in lung tissues in hemorrhage-lipopolysaccharide(LPS) two-hits rats and the effects of panaxadiols(PDS)and dexamthasone(Dex) on it.Methods The rat model of acute lung injury was built with hemorrhage-LPS two hits.The experiment was divided into control group(S),two-hits model group(HL),DEX group(HLD),and PDS group(HLP).The pathological changes of lung tissue were examined by HE staining.The expression of AQP1 was analyzed by RT-PCR,Western blotting and immunohistochemical staining.Results ① Significant inflammatory changes in pulmonary interstitial of rats in HL group were observed.However,in HLD group and HLP group,the pulmonary pathologic changes were much slighter.② AQP1 mRNA and protein expressions in lung tissues in HL group were significantly decreased compared with others groups(P
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Jilin University(Medicine Edition)
Année:
2006
Type:
Article