Drug Resistance and ?-Lactamases Produced by Acinetobacter baumannii in Lower Respiratory Tract Infection / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study the drug resistance and ?-lactamases produced by Acinetobacter baumannii isolated from lower respiratory tract.METHODS The drug sensitivity was detected with K-B test,and the ESBLs producing strains and ?-lactamases strains were screened by double disk test and confirmed by the NCCLS confirmation test.RESULTS Patients mostly were old from RICU,and broad-spectrum antibiotic therapy was applied,with history of re-oxygenating,sputa extraction and invasive operation.Fifteen received mechanical ventilation.Results of drug sensitivity showed almost all were resistant to FOX and CFZ,more than 70 percent resistant to CXM and MEZ,IPM and SCF,less than 10 percent resistant to AMX/CLAV,CAZ and OXL.There were no strains showing drug resistance to IPM,CAZ/CA and SCF.Test showed 5 strains(16%)produced AmpC enzyme and 9 strains(29%)produced ESBLs enzyme.CONCLUSIONS Rate of drug resistance is high,so drug susceptibility test should be enforced to guide reasonably clinical applying antibiotics in order to prevent outbreaks.