Recent progress in metastasis mechanism of malignant tumors and their treatment strategies / 中国肿瘤生物治疗杂志

ABSTRACT

Although great achievement has been made on the diagnosis and treatment of malignant tumors,metastasis of tumor remains to be the major reason for treatment failure and death of their victims.The development of systematic biology and functional genomics give us a deeper understanding of the nature of metastasis at the molecular level.Based on the consensus reached on the metastasis mechanisms of cancer,including the genetic heterogeneity of cancer,pre-metastatic niche,epithelial-mesenchymal transition,anoikis resistance,angiogenesis and lymphangiogenesis,etc,the targeted therapy at molecular level should be emphasized,the treatment should target the tumor stem cells,and RNAi technique and other techniques should be used in clinical anti-metastatic therapy.