Bioactive alkaloids from sponge-derived actinomyces sh6004 / 中国海洋药物
Chinese Journal of Marine Drugs
;
(6)1994.
Article
Dans Chinois
| WPRIM
| ID: wpr-592507
ABSTRACT
Objective To isolate and identify the antitumor components of the fermentation of the actinomyces sh6004 derived from a piece of sponge(unidentified)collected in Jiaozhou Bay.Methods The antitumor components were isolated by bioassay-guided fractionation and using solvent extraction,silica gel column chromatography and preparative HPLC.Their structures were established by physicochemical properties and spectral analyses.The cyto- toxicity of compound 4 and the antimicrobial activities of compounds were evaluated by SRB and paper disc method,respectively.Results and Conclusion Four alkaloid compounds were i- solated and identified as bisdethiobis-(methylthio)-gliotoxin(1),actinomycin D(2),actino- mycin C_(2a)(3)and aetinomycin C_3(4),respectively.Actinomycins were the main antitumor components produced by actinomyces sh6004.Compounds 1~4 showed antimicrobial activi- ties against Staphylococcus aureus and Bacillus subtilis at a concentration of 10?g?mL~(-1).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Marine Drugs
Année:
1994
Type:
Article
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