Pathogens and Their Resistance to Antibiotics from 878 Cerebrospinal Fluid Specimens / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To analyze the pathogenic results and drug resistance of bacteria isolated from cerebrospinal fluid specimens from Jan 2006 to Nov 2007 so as to provide evidence for clinical pathogenic analysis and selection of antibiotic.METHODS The bacteria identification and the antimicrobial susceptibility were assayed by VITEK-AMS system.RESULTS The positive rate of pathogens was 11.62% from 878 cerebrospinal fluid specimens.There were 102 strains of pathogens which included 19 Gram-positives,79 Gram-negatives and 4 fungi.The most frequently isolated pathogen was Pseudomonas(41.18%)followed by Staphylococcus haemolyticus(9.80%),Escherichia coli(8.82%),Acinetobacter spp(5.88%),Staphylococcus epidermidis(4.90%)and Shewanella putrefaciens(4.90%).The most active compounds against Gram-positive cocci were vancomycin(100.00%),linezolid(94.74%),nitrofurantoin(84.21%),tetracycline(78.95%),and rifampin(73.68%);The most active compounds against Gram-negative bacilli were piperacillin/tazobactam(75.95%),cefepime(58.23%),imipenem(54.43%),ciprofloxacin(53.16%) and levofloxacin(48.10%).CONCLUSIONS The prevailing pathogens in cerebrospinal fluid are Gram-negative bacilli,especially Pseudomonas and E.coli.Data collected in present study provide valuable information for prophylactic and empirical antibiotic use in intracranial infection.