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Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test
Article de En | WPRIM | ID: wpr-59306
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. METHODS: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 microl) into the hind paw. Curcumin doses of 62.5, 125, 250, and 500 microg were delivered through an intrathecal catheter to examine the flinching responses. The ED50 values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale. RESULTS: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the ED50 value (95% confidence interval) of curcumin was 511.4 microg (23.5-1126.5). There was no apparent abnormal behavior following the administration of curcumin. CONCLUSIONS: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Moelle spinale / Mesure de la douleur / Cathétérisme / Modèles linéaires / Rat Sprague-Dawley / Curcumine / Cathéters / Formaldéhyde Limites du sujet: Animals / Humans / Male langue: En Texte intégral: The Korean Journal of Pain Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Moelle spinale / Mesure de la douleur / Cathétérisme / Modèles linéaires / Rat Sprague-Dawley / Curcumine / Cathéters / Formaldéhyde Limites du sujet: Animals / Humans / Male langue: En Texte intégral: The Korean Journal of Pain Année: 2012 Type: Article