Relationship between haplotypes of brain-derived neurotrophic factor gene and sporadic Alzheimer's disease / 临床神经病学杂志

ABSTRACT

Objective To analysis the relationship between the single nucleotide polymorphisms (SNPs) of G196A, C270T, G11757C, G712A and haplotypes frequencies of brain-derived neurotrophic factor (BDNF) gene and Chinese Han population with sporadic Alzheimer's disease (sAD). Methods The genotype and allele frequencies of BDNF G196A, C270T, G11757C and G712A were analyzed by polymerase chain reaction-restriction fragment length polymorphism technology in 106 sAD patients and 110 healthy controls. The software SHEsis was used to analyze the linkage disequilibrium and the haplotypes between the two groups. Results There were statistically differences in T allele frequeny of C270T (sAD vs control 0.9% vs 4.5%) and A allele freguency of G712A (sAD vs control 0.5% vs 4.5%) and in GG genotype frequeny of G712A (sAD vs control 95.4% vs 91.8%) (all P