Detection and Drug-resistance Analysis of Extended Spectum ?-Lactamases Producing Escherichia coli and Klebsiella pneumoniae / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate drug resistance characteristice of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum?-lactamases(ESBLs) in our hospital so as to instruct rational use of antibiotics in clinic. METHODS The ESBLs were determined by the sensitivity and confirming tests according to NCCLS(1999) standard. RESULTS The isolated ratio of ESBLs producing E. coli and K. pneumoniae increased from 28.6% and 29.2% in 2005 to 48.5% and 49.2% in 2007. Extended-Spectum ?-Lactamases germs showed high resistance to cephalosporins-1G, 2G, 3G, to Penicillin and to Am Aztreonam. The rate of sensitivity to imipenem was 100.0%. CONCLUSIONS There is an increasing trend of ESBLs producing E. coli and K. pneumoniae. The imipenem is the best drug for treatment the bacterium producing ESBLs.