Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders
Annals of Rehabilitation Medicine
; : 340-346, 2012.
Article
Dans En
| WPRIM
| ID: wpr-59512
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE: To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires. METHOD: A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance. RESULTS: DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value. CONCLUSION: Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Glande parotide
/
Glandes salivaires
/
Ptyalisme
/
Sorbitol
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Toxines botuliniques
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Tyramine
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Études de suivi
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Toxines botuliniques de type A
/
Maladies du système nerveux
Type d'étude:
Observational_studies
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Prognostic_studies
/
Qualitative_research
Limites du sujet:
Child
/
Humans
langue:
En
Texte intégral:
Annals of Rehabilitation Medicine
Année:
2012
Type:
Article