Nasopharyngeal Carcinoma in Children and Adolescents: Single Institution Study / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 114-120, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-59585
ABSTRACT
BACKGROUND:
Nasopharyngeal carcinoma (NPC) is very rare in children and adolescents. The aim of this study was to evaluate clinical characteristics and treatment outcomes of pediatric NPC.METHODS:
Medical records of 9 patients treated for NPC at the Seoul National University Children's Hospital between 1988 and 2012 were analyzed retrospectively.RESULTS:
The median age at diagnosis was 11 years (range, 9-13 years). One patient had stage II disease, 3 had stage III disease, and 5 had stage IV disease. The histologic subtypes were undifferentiated carcinoma and squamous cell carcinoma in 7 and 2 patients, respectively. All patients were initially treated with cisplatin (100 mg/m2 intravenous [IV] every 4 weeks for 4-6 months), bleomycin (15 unit/m2 IV every 1 weekx7), and fluorouracil (1,000 mg/m2 IV every 4 weeks for 1 year). Eight patients received radiotherapy with doses of 45-59.4 Gy at the primary site and neck nodes. Seven patients (77.8%) achieved complete remission, 1 (11.1%) achieved partial remission, and 1 (11.1%) showed disease progression. Six patients developed fluorouracil-related neurotoxicity; the regimen was changed to cisplatin, epirubicin, and bleomycin in five of the 6 patients. One patient died of progressive disease without responding to treatment. Treatment-related mortality occurred in 1 patient owing to septic shock. Secondary osteosarcoma developed in 1 patient 6 years after treatment. The overall survival was 77.8%, with a median follow-up of 40.8 months (range, 4.5-287.6 months).CONCLUSION:
Children and adolescents with advanced NPC treated with combined chemotherapy and radiotherapy have a good survival rate.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pédiatrie
/
Radiothérapie
/
Choc septique
/
Bléomycine
/
Carcinomes
/
Carcinome épidermoïde
/
Épirubicine
/
Ostéosarcome
/
Tumeurs du rhinopharynx
/
Dossiers médicaux
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adolescent
/
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Clinical Pediatric Hematology-Oncology
Année:
2014
Type:
Article
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