Relationship between Atopic Status and Immunoregulatory Cytokines in Respiratory Syncytial Virus Bronchiolitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 30-37, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-59704
ABSTRACT
PURPOSE:
Recent studies have demonstrated and suggested that Interleukin (IL) -10 and IL-11 are implicated in the pathophysiology of RSV infection and may act in the regulation of inflammatory response. We measured IL-10 and IL-11 in nasal secretions of infants with acute RSV bronchiolitis to investigate if there is any difference in the production of these anti-inflammatory cytokines between atopic and non-atopic subjects.METHODS:
We measured IL-10, IL-11 in nasal secretions of 44 infants (20 were atopic) with acute RSV bronchiolitis. The nasal secretion samples were obtained from patients on admission and stored immediately at -70degrees C until analysis. Atopy was defined as having at least one positive skin prick test to common allergens, a positive history of atopic dermatitis or age-matched, high serum IgE level.RESULTS:
IL-10 and IL-11 increased significantly in nasal secretion of infants with acute RSV bronchiolitis. Both IL-10 and IL-11 were significantly lower in atopic patients than in non-atopic patients. There was no significant relation between the severity of symptoms and IL-10 or IL-11 levels.CONCLUSION:
Our study showed that both IL-10 and IL-11 increased in nasal secretion during acute RSV bronchiolitis, and the levels were significantly lower in atopic patients than in non-atopic patients. It suggests that the airway inflammation induced by RSV may be different between atopic and non-atopic patients and this may be associated with lower induction of these anti-inflammatory cytokines in atopic patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virus respiratoires syncytiaux
/
Peau
/
Immunoglobuline E
/
Bronchiolite
/
Allergènes
/
Cytokines
/
Interleukines
/
Interleukine-10
/
Interleukine-11
/
Eczéma atopique
Limites du sujet:
Humains
/
Bébé
langue:
Coréen
Texte intégral:
Pediatric Allergy and Respiratory Disease
Année:
2004
Type:
Article
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