Expression of human glucocorticoid-induced tumor necrosis factor receptor in the synovial of patients with rheumatoid arthritis / 中华风湿病学杂志

ABSTRACT

Objective To investigate the expression of human glucocorticoid-induced tumor necrosis factor receptor(hGITR)in synovial and cartilage tissue of patients with rheumatoid arthritis(RA),and analyze their relationships with the severity of synovial inflammation in RA.Methods Expression of hGITR in synovial and cartilage biopsy material of 16 RA patients,9 osteoarthritis(OA)patients,4 contmIs were detected in situ by immunohistochemical technique and the results were analyze then.Results hGITR was strongly expressed in the vascular endothelial cells and inflammatory cells in RA and hGITR positive cells could be detected in approximately 69%of RA synovial cells.Significant differenee Was foand in hGITR expression between RA patients and control group(P<0.01).hGITR was less expressed in the cartilage than the synovial in RA.No significant difference was found in expression in the cartilage tissue expression between RA patients and the control group.Significant difference Was found in hGITR expression between synovial and cartilage in RA.Furthermore.the hGITR positive cells in synovial tissues were also found to correlate significandy with the severity of synovial inflammation in RA patients(r=0.895,P<0.01).Conclusion These results suggest that the abnormal expression of hGITR in the synovial my bean important mechanism leading to the synovial destruction found in RA.