The Effects of Asiaticoside on Fibroblasts in vitro Culture / 中山大学学报(医学科学版)

ABSTRACT

【Objective】 To investigate the possible mechanism of the asiaticoside used for the treatment of hypertrophic scar. 【Method】 Using microscope, electron microscope, MTT test, 3　H-TdR and 3　H-Pro line incorpo ration to study the effect of the asiaticoside on DNA synthesis and collagen bi osynthesis of fibroblast in vitro culture. 【Results】 The asiaticoside not only affected the ultrostructure of fibroblast, but also inhibted the DNA synthesis a nd collagen biosynthesis.【Conclusion】 Asiaticoside can play an important role in the prevntion and treatment of scars, the mechanism may be that the asiaticos ide can inhibted the DNA synthesis and collagen biosynthesis of fibroblast.