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Diagnostic Benefit of Thyroglobulin Measurement in Fine-Needle Aspiration for Diagnosing Metastatic Cervical Lymph Nodes from Papillary Thyroid Cancer: Correlations with US Features
Korean Journal of Radiology ; : 106-111, 2009.
Article Dans Anglais | WPRIM | ID: wpr-60042
ABSTRACT

OBJECTIVE:

Our goals were to determine the added value of fine-needle aspiration biopsy (FNAB)-thyroglobulin (Tg) measurements over FNAB-cytology alone for diagnosing metastatic nodes, and to determine whether the ultrasound features of lymph nodes can be used to identify lymph nodes that may benefit from FNAB-Tg measurement in patients with papillary thyroid cancer. MATERIALS AND

METHODS:

We retrospectively evaluated 76 surgically proven cervical lymph nodes. Twenty-nine patients were awaiting surgery and 18 patients had undergone thyroid surgery for papillary thyroid cancer. Ultrasound-guided FNAB and Tg measurements were performed and the ultrasound features were evaluated.

RESULTS:

The accuracies, sensitivities, and specificities of FNAB-cytology, FNAB-Tg, and combined FNAB-Tg/cytology were 90%, 80%, and 100%; 92%, 95%, and 90%; and 93%, 96%, and 90%, respectively. The diagnostic sensitivity of FNAB-Tg for metastatic nodes was significantly higher than that of FNAB-cytology (p = 0.011). Furthermore, combined FNAB-Tg/cytology significantly increased sensitivity (p = 0.002) and accuracy (p = 0.03) as compared with FNAB-cytology.

CONCLUSION:

Combined FNAB-Tg/cytology is significantly more sensitive and accurate at detecting metastatic nodes than FNAB-cytology alone. FNAB-Tg was better at diagnosing metastases in small lymph nodes.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Thyroglobuline / Tumeurs de la thyroïde / Carcinome papillaire / Études rétrospectives / Sensibilité et spécificité / Échographie interventionnelle / Cytoponction / Noeuds lymphatiques / Métastase lymphatique Type d'étude: Etude diagnostique / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Journal of Radiology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Thyroglobuline / Tumeurs de la thyroïde / Carcinome papillaire / Études rétrospectives / Sensibilité et spécificité / Échographie interventionnelle / Cytoponction / Noeuds lymphatiques / Métastase lymphatique Type d'étude: Etude diagnostique / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Journal of Radiology Année: 2009 Type: Article