Increase of procalcitonin in infant muggy syndrome / 中国小儿急救医学

ABSTRACT

Objective To investigate the characteristics and clinical significance of increased procal-citonin( PCT) in infant muggy syndrome( IMS) .Methods A total of 23 IMS cases admitted in PICU from Nov 2011 to Apr 2012 were enrolled.All cases were devided into three groups according to pediatric critical illness score,high risk group(n=5),medium risk group(n=12),and mild risk group(n=6).And 23 cases were also divided into infection group and no infection group according to baseline disease before onset.The relationship of PCT and pediatric critical illness score,primary infectino and infection index weer observed, and the possible causes of icn reased PCT in IMS were explored.Twenty age mathc ed infants reec iving exami-nation in clinic served as control gor up.Re sults PCT inrc eased significantly in IMS cases.The PCT level was(91.5 ±90.9) ngm/l ni high risk group,(81.1 ±74.1) ng/ml in medium risk group,and(112.1 ± 74.9) ng/ml in mild risk group,there were no significant differences among trh ee groups( F=0.371,P =0.732).Other infection index like leukocyte conmt,neutrophil and C reactvi e prto ein in IMSg roup were higher thant hose int he cno trol group,and the results had significant differences( P<0.05,reps ectively) .The PCT level was(72.5 ±74.4) ng/ml in infce toi n group,(101.5 ±76.6) ng/ml in no infection rg oup,and there was on sing ificant difference between two groups(t=0.873,P=0.392).There was no relevance be-tween increase of PCT and the incidence of infection before IMS.But PCT had higher correlation to the body tem-perature after IMS(r=-0.362,P=0.049).Conclusion There is correlation between the increased PCT and fever in IMS,and fever in IMS would lead to inflammation and then resulted in the increase of PCT.