Determination of Trace Nickel in Agomelatine by Inductive Coupled Plasma Atomic Emission Spectrometry / 中国药师
China Pharmacist
;
(12): 1030-1031,1032, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-601441
ABSTRACT
Objective:
To establish a method for the determination of trace nickel in agomelatine.Methods:
An inductive coupled plasma atomic emission spectrometry method was applied in the determination at 221. 648 nm. The sample solution was prepared by the ignited residue of agomelatine. The content of nickel was determined using the standard curve.Results:
The linear range was 0. 025-1. 000 μg·ml-1(r=0. 999 8). The RSD of precision was 0. 63%. The detection limit was 0. 000 8μg·ml-1. The quantitative limit was 0. 003μg·ml-1 . The average recovery was 99. 4% with RSD of 2. 20%. The RSD of repeatability was 1. 33%.Conclusion:
The method is simple, sensitive and accurate in the determination of trace nickel in agomelatine.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2015
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS