Expression of Topo Ⅱ in osteosarcoma after chemotherapy and its significance / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 689-690,694, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-601536
ABSTRACT
Objective To probe into the content of DNA Topo Ⅱ in osteosarcoma after chemotherapy.Methods 30 patients with osteosarcoma received two courses of chemotherapy treatment before the surgical resection of the tumor tissue.Then immunohistochemistry was used to detect the content of Topo Ⅱ in tissues and detected its relationship in pathology.Results There were 8 out of 30 cases in which Topo Ⅱ was presented positive in osteosarcoma (26.7 %).The protein content of Topo Ⅱ was unrelated to the patient' s age,gender,degree of tumor malignancy,tumor location and translocation or Enneking staging (P > 0.05),but related to patients survival rate (P < 0.05).Conclusion Patients with lower expression of Topo Ⅱ are more likely to have poor prognosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Cancer Research and Clinic
Année:
2014
Type:
Article
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