Detection of serum IL-17,ECP and IgE concentrations in patients with bronchial asthma and the correlation study / 国际检验医学杂志

ABSTRACT

Objective To study the relationship between serum interleukin‐17(IL‐17) ,acidophil cationic protein(ECP) ,immuno‐globulin E(IgE) and the severity of asthma .Methods A total of 84 patients with asthma were enrolled as asthma group ,who were divided into remission group and acute episode group .In addition to that 84 healthy persons were recruited as control group .The concentrations of serum IL‐17 ,ECP and IgE in different groups were compared .Results The concentrations of serum IL‐17 ,ECP and IgE in asthma group were statistically significantly higher than those in control group(P< 0 .05) .Among the patients with bronchial asthma ,serum levels of ECP and IgE in acute episode group were statistically significantly higher than those in remission group(P<0 .05) .There was positive correlation between serum ECP level and serum IgE level in asthma group(r=0 .432 ,P<0 .05) ,there was no significant correlation between serum IL‐17 level and serum levels of ECP and IgE ,but in acute episode group , serum IL‐17 level positively correlated with serum levels of ECP and IgE(r= 0 .327 ,0 .349 ,P< 0 .05) .Conclusion IL‐17 is in‐volved in mediating eosinophilic inflammation of asthma ,ECP and IgE levels have important clinical significances for predicting and treating asthma patients .