Metabonomics-based methods for metabolic disease:research advances / 国际药学研究杂志

ABSTRACT

As a new technology of 'omics', m etabonomics is a comprehensive tool employed to investigate the metabolic response of living systems to endogenous and exogenous stimuli. It can link phenotypes with the changes at molecular level, which is helpful to uncovering the metabolic changes during the development of disease and to explore the possible pathogenesis. With the change of diet and living habits, the incidences of metabolic diseases such as hypertension and diabetes are increasing, seriously affecting people′s health and safety, so it is important to explore the pathogenesis as an assistant way of clinical diagnosis and treatment. Recently, the study of various metabolic diseases has achieved a certain progress. This paper gives a brief introduction to metabonomics and an overview of the latest progress in metabonomics applied in the study of metabolic diseases such as obesity, diabetes, hypertension, hyperlipidemia and metabolic syndrome.