The effects of different dose of clopidogrel on clopidogrel resistance,platelet aggregation rate and hypersensitive level of patients with acute coronarysyndrome / 重庆医学

ABSTRACT

Objective To explore the effects of different dose of clopidogrel on clopidogrel resistance ,platelet aggregation rate and inflammatory factor level of patients with acute coronary syndrome .Methods Totally 98 cases of acute coronary syndrome patients were randomly divided into the observation group and the control group two groups according to the order of treatment ,49 cases in each group .The two groups were treated with conventional percutaneous coronary artery intervention (PCI) ,and the con‐trol group was treated with low dose clopidogrel ,while the observation group was given high loading dose of clopidogrel .The deter‐mination of platelet aggregation rate (PA ) and inflammatory factor hypersensitive C‐reactive protein (hs‐CRP) level respectively before treatment and after treatment 2 ,6 ,24 and 48 h were observed ,and the clopidogrel resistance (CR) occurrence of two groups were assessed .Results The CR of observation group was significantly lower than the control group ,the difference statistically sig‐nificant (P 0 .05) .Conclusion High dose of clopidogrel has better curative effect in pa‐tients with acute coronary syndrome ,and can more effectively inhibit platelet aggregation ,reduce the incidence of clopidogrel resist‐ance and the levels of inflammatory factors ,fewer adverse reactions ,and worth the clinical promotion and application .