Expression and clinical significance of MTUS 1 gene in papillary thyroid carcinoma / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
;
(6): 272-274,279, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-602715
ABSTRACT
Objective To study the expression of mitochondrial tumor suppressor gene 1 (MTUS1) mR-NA in papillary thyroid carcinoma(PTC).Methods Reverse transcription polymerase chain reaction(RT-PCR) was used to detect MTUS1 mRNA level in 68 cases of human PTC and the adjacent non-cancerous epithelium (NCE) specimens.Results The relative expression value of MTUS1 mRNA in PTC was 0.31 ± 0.09,while it was 0.65 ±0.12 in NCE.The difference had statistical significance between the 2 groups(t =2.39,P <0.05).In PTC,mRNA expression of MTUS1 gene was related to the pathological grade,and lymph node metastasis(P < 0.05)while it was not related to patients' age,sex,differentiation degree,tumor size or TNM stage(P > 0.05).Conclusion mRNA expression of MTUS1 gene is lower in PTC than in NCE,which may play an important role in carcinogenesis and progression of PTC.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Endocrine Surgery
Année:
2015
Type:
Article
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