Caenorhabditis elegans:an model organism for gut flora-host interactions research / 军事医学

ABSTRACT

Gut microbes play an important role in human health and are believed to be closely related to obesity , diabetes and some other metabolic diseases .Recently, intestinal flora has become a research hotspot and new target for disease prevention.The problems facing intestinal flora research included variability between individuals ,huge amounts and varieties of gut microbes .Caenorhabditis elegans, with the advantages of living on E.coli, short growth periods , easy observation,applicability to high throughput screening of drugs , is an ideal model organism for research of microbe-host interactions .It has been used in probiotics screening and interaction mechanism research of multifold bacteria .This review summarizes some new researches and applications in this area .