Drug Therapy for Osteonecrosis of the Femoral Head / 대한정형외과연구학회지

ABSTRACT

Total hip replacement arthroplasty is performed in many cases of osteonecrosiss of the femoral head(ONFH). However, there are still problems associated with postoperative functional limitation and revision arthroplasty due to wear of implants because ONFH usually occurs at relatively young adults. Therefore, the efforts to promote regeneration of ONFH or to delay progression of the disease should be required. Recently, the use of pharmacological agents for the treatment of ONFH has been introduced based on several hypotheses of pathophysiology or risk factors for ONFH. We describe theoretical rationale and short-term clinical results of pharmacological treatments for ONFH.