Effect of bifidobacterial lipoteichoic acid on cellular immunity of mice with systemic Candida albicans infection / 重庆医学

ABSTRACT

Objective To observe the effect of bifidobacterial lipoteichoic acid (BLTA) on cellular immunity of mice with systemic Candida albicans infection .Methods Systemic C .albicans infection model in immunocompromised mice were established by injecting standard strain of C .albicans via caudal vein .The effects of BLTA on thymus index ,spleen index ,splenic lymphocytes proliferation and NK cells cytotoxicity were observed as well as serum levels of cytokines .Results After systemic C .albicans infec‐tion in immunocompromised mice ,thymus index ,spleen index and splenic lymphocytes proliferation activity were decreased (P>0 .05) ,NK cells cytotoxicity was decreased significantly (P0 .05) ,IL‐10 levels were increased significantly(P<0 .05) .After treated by BLTA ,thymus index ,spleen index ,splenic lymphocytes proliferation and NK cells cytotoxicity were increased significantly (P<0 .01) ,IL‐2 and INF‐γ levels were increased significantly (P<0 .05) ,IL‐4 levels showed little change ,IL‐10 levels were decreased significantly (P<0 .01) .Conclusion BLTA can improve immune status of immunocompromised mice ,which can restore and enhance the compromised cellular immunity of mice with sys‐temic C .albicans infection .