Effects of Pancreatic Polypeptide on the Secretion of Enzymes and Electrolytes by in Vitro Preparations of Rat and Cat Pancreas
Yonsei Medical Journal
;
: 99-105, 1980.
Article
Dans Anglais
| WPRIM
| ID: wpr-60600
ABSTRACT
Pancreatic polypeptie (PP) is released from the pancreas in response to vagal stimulation. Amongst other effects, PP has been reported to inhibit pancreatic exocrine function. Apart from any potential physiological role, such inhibition could have important consequences for in vitro studies of pancreatic function employing acetylcholine as a stimulus. We have therefore tested the effect of bovine PP on two in vitro pancreatic preparations the incubated, uncinate pancreas of young rats and the perfused cat pancreas. In the former, PP (10(-10)-10(-8)M) had little or no effect on enzyme discharge or45Ca efflux under basal conditions or during stimulation with caerulein, CCK-PZ or acetylcholine. In the perfused cat pancreas, similar concentrations of PP were also without effect on fluid secretion evoked by secretin infusion, or enzyme discharge evoked by CCK-PZ injection or infusion. We conclude that bovine PP has no direct effects on the cellular mechanisms responsible for pancreatic electrolyte secretion or enzyme discharge in the species studied.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pancréas
/
Perfusion
/
Techniques in vitro
/
Céruléine
/
Cholécystokinine
/
Polypeptide pancréatique
/
Sécrétine
/
Acétylcholine
/
Calcium
/
Électrolytes
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
1980
Type:
Article
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