Identification on biological characteristics of AIV H5N1 monoclonal antibody / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 398-400,406, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-606432
ABSTRACT
Objective:
To investigate the biological characteristics of monoclonal antibodies against avian influenza virus (AIV).Methods:
Monoclonal antibodies (mAbs) against AIV H5N1 were prepared and it′s characteristics were identified including subtype,titer,hemagglutination inhibition activity and cross-reactivity with other influenza viruses.Besides,Western blot and immuno-histochemical staining methods were conducted to test the combination of antibodies and antigen ( H5N1 ) and human normal tissues.Results:
Immunohistochemical analysis showed that 2 mAbs (H5-32 and H5-35) cross-reacted with human tissues kidney and pancreas respectively.Conclusion:
These data indicated that there have some association between the AIV H 5N1 with human tissues, which may provide reference for the study on avian influenza virus infection and pathogenicity .
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude diagnostique
/
Étude pronostique
langue:
Chinois
Texte intégral:
Chinese Journal of Immunology
Année:
2017
Type:
Article
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