Effects of aerobic exercise time on cardiovascular and renal functions of 2K1C renal vascular hypertensive rats / 中国病理生理杂志

ABSTRACT

AIM: To explore the impact of aerobic exercise (AE) time on mean arterial pressure (MAP), sinus bradycardia, heart and kidney histological changes and oxidative damage in the two-kidney and one-clip (2K1C) hypertensive rats, and to assess the specific effects of AE time on alleviation of hypertension.METHODS: Healthy male Wistar rats (n=60) were randomly divided into sham operation (sham) group and 2K1C group.After operation, the rats in these 2 groups were divided into sham sedentary (sham+SED) group, sham exercise (sham+AE) group, 2K1C se-dentary (2K1C+SED) group and 2K1C exercise (2K1C+AE) group.The rats in sham+AE group and 2K1C+AE group were subjected to AE for 10 weeks: swimming for 1 h/d.The MAP, sinus bradycardia and the histological changes of heart and kidney in these 4 groups were tested regularly.RESULTS: Compared with 2K1C+SED group, the rats in 2K1C+AE group had significantly improved MAP and sinus bradycardia at the 4th week, with reduced collagen deposition in the myocardium and kidney, decreased level of thiobarbituric acid reactive substances (TBARS) in the left ventricle and increased catalase (CAT) activity in the left ventricle and kidney.The results of the 6th to 10th weeks showed that the differences of MAP and sinus bradycardia between the rats in 2K1C+AE group and 2K1C+SED group had gradually narrowed.The TBARS levels in the left ventricle and kidney and CAT activity in both kidneys of the rats in 2K1C+AE group were partly restored at the 8th week.The collagen deposition in the heart and kidney of the rats in AE group was reduced to the lowest level at the 10th week.CONCLUSION: Short-time (about 4 weeks) AE effectively improves the MAP and sinus bradycardia of 2K1C renal vascular hypertensive rats and attenuates the damages of the heart and kidney by regulating oxidative stress, thus improving the cardiovascular and renal functions of 2K1C renal hypertensive rats.