Preparation and in vitro Drug Release of Daptomycin Liposomes / 中国药师
China Pharmacist
;
(12): 827-832, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-610178
ABSTRACT
Objective:
To prepare daptomycin liposomes and investigate the in vitro drug release.Methods:
Daptomycin liposomes were prepared by an active loading method.The distribution of particle size and zeta potential of liposomes were determined by a laser particle size analyzer.The encapsulation efficiency and in vitro drug release were determined by HPLC.Results:
The particle size of daptomycin liposomes was 109.5 nm, the heterogeneous dispersion coefficient was 0.042 and the zeta potential was-6.48 mV.The entrapment efficiency determined by gel column and centrifugation was 50.8% and 50.3%, respectively.The result of in vitro drug release showed that daptomycin liposomes had a good sustained-release effect when compared with daptomycin for injection.Conclusion:
Daptomycin liposomes have uniform particle size, which can release drug slowly to reduce administration frequency.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2017
Type:
Article
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